Neural Circuits/Learning and Memory

Research

Neural Circuits / Learning and Memory

Learning and memory are crucial for high-level cognitive behavior. The hippocampus plays important roles in memory formation and retrieval through sharp-wave-ripples. It has been hypothesized that certain neuron populations in the cortex exhibit coordinated activity with the hippocampus during learning and memory retrieval. We develop technologies to study information processing in the brain and the hippocampus as well as biophysical models to investigate mechanisms of hippocampal-cortical memory transfer.

Relevant references:

-Liu X, Terada S, Ramezani M, Kim JH, Lu Y, Grosmark A, Losonczy A, Kuzum D. E-Cannula reveals anatomical diversity in sharp-wave ripples as a driver for the recruitment of distinct hippocampal assemblies. Cell Reports. 4;41(1), 2022.

-Liu X, Ren C, Lu Y, Liu Y, Kim JH, Leutgeb S, Komiyama T, Kuzum D. Multimodal neural recordings with Neuro-FITM uncover diverse patterns of cortical–hippocampal interactions. Nature neuroscience.;24(6):886-96, 2021.

-Liu X, Kuzum D. Hippocampal-cortical memory trace transfer and reactivation through cell-specific stimulus and spontaneous background noise. Frontiers in Computational Neuroscience. 24;13:67, 2019

-Canakci S, Toy MF, Inci AF, Liu X, Kuzum D. Computational analysis of network activity and spatial reach of sharp wave-ripples. PloS one.12(9):e0184542, 2017.