Recent progress in stem cell technology has yielded human cortical organoids, three-dimensional neuronal networks derived from differentiated human induced pluripotent stem cells to exhibit some emergent features of the cerebral cortex. Brain organoids show promise as the next generation of disease models, platforms for drug screening and personalized medicine, and transplantable neural prosthetics to restore specific lost, degenerated, or damaged brain regions. Our goal is to develop electronic interfaces to human brain organoids to study and facilitate structural and functional maturation and integration in vitro and in vivo.

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